Key result
Pulmonary vascular hemodynamic stress is directly linked to vascular remodeling, dysfunction, and pulmonary hypertension.
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A comprehensive summary of current understanding regarding how hemodynamic stress initiates complex molecular and cellular signaling pathways leading to pulmonary hypertension.
Hemodynamic stress in the pulmonary vessel is directly linked to the development of vascular remodeling and dysfunction, ultimately leading to pulmonary hypertension. Recently, some advances have been made in our molecular understanding of the exogenous upstream stimuli that initiate hemodynamic pertubations as well as the downstream vasoactive effectors that control these responses. However, much still remains unknown regarding how these complex signaling pathways connect in order to result in these characteristic pathophysiological changes. This chapter will describe our current understanding of and needed areas of research into the clinical, physiological, and molecular changes associated with pressure/volume overload in the pulmonary circulation.
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Chan et al. (2010) conducted a review in Pulmonary hypertension and pulmonary vascular disease. Hemodynamic stress (pressure/volume overload) was evaluated. Hemodynamic stress in the pulmonary vasculature is directly linked to the development of vascular remodeling and dysfunction, ultimately leading to pulmonary hypertension.
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