Antimicrobial agents are used in more than 60% of ICU patients for several reasons. Frequent use of antimicrobial agents contributed developing to resistant both of gram positive and gram negative bacteria. Methicillin resistant staphylococcus aureus (MRSA), vancomycin resistant enterococcus (VRE), glycopeptide-intermediate S.aureus (GISA), Extended-spectrum beta-lactamases (ESBL) positive Escherichia coli, Klebsiella spp, Enterobacteriaceae spp, Acinetobacter spp and Pseudomonas aeruginosa are resistant microorganisms that caused various infection by using of antimicrobial agents in ICUs Especially the use of third generation cephalosporins, fluoroquinolones and carbapenem derivatives play an important role in the development of nosocomial infections caused by resistant bacteria
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Calik et al. (2015) studied this question.
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