Key result
In stable outpatients with dilated cardiomyopathy, high biological variation in plasma renin concentration was a significant independent predictor of high biological variation in BNP (P=0.002).
Observational (n=115)
No
Effect estimate: β=0.276
p-value: p=0.002
In stable outpatients with dilated cardiomyopathy, biological variation in BNP is significantly correlated with variations in plasma renin concentration and hematocrit, suggesting that subclinical changes in circulating volume influence these biomarkers.
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May reflect subclinical volume shifts in stable dilated cardiomyopathy; hypothesis-generating and should not yet change practice.
Nishiyama et al. (2011) conducted an observational in Dilated Cardiomyopathy (DCM) with stable chronic heart failure (n=115). Biological variation in plasma renin concentration (PRC) was evaluated on Biological variation in B-type natriuretic peptide (BNP) (β=0.276, p=0.002). In stable outpatients with dilated cardiomyopathy, high biological variation in plasma renin concentration was a significant independent predictor of high biological variation in BNP (P=0.002).
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