Frontal variant of Аlzheimer's disease

Alzheimer’s disease (AD) is a chronic neurodegenerative disease, that is the most common cause of dementia. Late on-set AD is usually associated with the classic picture of short-term memory deficits, while early onset AD demonstrates atypical symptoms. The frontal variant is the rarest non-amnestic AD phenotype, which associated with selective neurodegeneration in frontal control networks, which is confirmed by the presence of biomarkers of amyloid pathology. The clinical picture includes a wide variety of symptoms, including disinhibition, apathy, compulsive behavior and executive dysfunction, which often leads to difficulties in making a differential diagnosis with the behavioral variant of frontotemporal dementia) and, as a result, underestimation of the true prevalence of AD. The article provides a brief review of modern literature and a description of two clinical cases of the frontal variant of AD, confirmed by the study of cerebrospinal fluid biomarkers.