Key result
Activation of the classical renin-angiotensin system axis potentiates stress-related cardiovascular, endocrine, and behavioral responses, while stimulation of the counter-regulatory axis attenuates these effects.
Why the study?
The renin-angiotensin system plays essential roles in stress, motivating a summary of current knowledge on the participation of its components across different adverse environmental stressors.
Does pharmacological modulation of the renin-angiotensin system improve stress-related cardiovascular, endocrine, and behavioral responses in stress models?
Does pharmacological modulation of the renin-angiotensin system improve stress-related cardiovascular, endocrine, and behavioral responses in stress models?
Pharmacological modulation of the renin-angiotensin system with ACE inhibitors or ARBs offers a promising therapeutic perspective for stress-related disorders by attenuating stress responses.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for RAS modulation in stress disorders; prospective human trials needed before clinical consideration.
: Along with other canonical systems, the renin-angiotensin system (RAS) has shown essential roles in stress. This system is a complex regulatory proteolytic cascade composed of various enzymes, peptides, and receptors. Besides the classical (ACE/Ang II/AT 1 receptor) and the counter-regulatory (ACE2/Ang-(1-7)/Mas receptor) RAS axes, evidence indicates that non-classical components, including Ang III, Ang IV, AT 2, and AT 4, can also be involved in stress. Objective and methods: This comprehensive review summarizes the current knowledge on the participation of RAS components in different adverse environmental stimuli stressors, including air-jet stress, cage switch stress, restraint stress, chronic unpredictable stress, neonatal isolation stress, and post-traumatic stress disorder. Results and conclusion: In general, activating the classical RAS axis potentiates stress-related cardiovascular, endocrine, and behavioral responses, while the stimulation of the counter-regulatory axis attenuates these effects. Pharmacological modulation in both axes is optimistic, offering promising perspectives for stress-related disorders treatment. In this regard, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are potential candidates already available because they block the classical axis, activate the counter-regulatory axis, and are safe and efficient drugs.
No takes yet. Share an insight, caveat, or question.
Correa et al. (2021) conducted a review in Stress and stress-related disorders. Renin-angiotensin system modulators (ACE inhibitors and ARBs) was evaluated. Activation of the classical renin-angiotensin system axis potentiates stress-related cardiovascular, endocrine, and behavioral responses, while stimulation of the counter-regulatory axis attenuates these effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: