Why the study?
Does cilazapril reduce ambulatory blood pressure in healthy young men?
Population
16 healthy young men, mean age 25.3 +/- 1.6 years
Comparison
Cilazapril 2.5 mg oral once daily for 7 days vs Placebo
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
7 days
Authors
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Transient BP reduction without 24-h mean change limits sustained efficacy in normotensives; extends time-course data for cilazapril in healthy young men.
Does cilazapril reduce ambulatory blood pressure in healthy young men?
Cilazapril 2.5 mg daily for 7 days transiently reduces systolic and diastolic blood pressure 1.5 to 6 hours post-dose in healthy young men, without significantly altering 24-hour mean blood pressure.
Schmidt et al. (1992) studied this question.
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