Key result
Patients with comorbid migraine and insomnia exhibited shared functional connectivity alterations in the dorsomedial prefrontal and posteromedial cortex subnetworks compared to healthy controls.
Why the study?
Migraine and insomnia are commonly comorbid and linked to default mode network disturbance, but the relative contributions of default mode network subnetworks in this comorbidity remain largely unknown.
Observational
Migraine and insomnia share functional connectivity disturbances in specific default mode network subnetworks, which may underlie their comorbidity.
Shared DMN alterations may underlie migraine-insomnia comorbidity; hypothesis-generating and requires prospective validation before clinical translation.
Migraine is commonly comorbid with insomnia; both disorders are linked to functional disturbance of the default mode network (DMN). Evidence suggests that DMN could be segregated into multiple subnetworks with specific roles that underline different cognitive processes. However, the relative contributions of DMN subnetworks in the comorbidity of migraine and insomnia remain largely unknown. This study sought to identify altered functional connectivity (FC) profiles of DMN subnetworks in the comorbidity of migraine and insomnia. Direct group comparisons with healthy controls, followed by conjunction analyses, were used to identify shared FC alterations of DMN subnetworks. The shared FC changes of the DMN subnetworks in the migraine and insomnia groups were identified in the dorsomedial prefrontal and posteromedial cortex subnetworks. These shared FC changes were primarily associated with motor and somatosensory systems, and consistently found in patients with comorbid migraine and insomnia. Additionally, the magnitude of FC between the posteromedial cortex and postcentral gyrus correlated with insomnia duration in patients with comorbid migraine and insomnia. Our findings point to specific FC alterations of the DMN subnetwork in migraine and insomnia. The shared patterns of FC disturbance may be associated with the underlying mechanisms of the comorbidity of the two disorders.
No takes yet. Share an insight, caveat, or question.
Chou et al. (2021) conducted an observational in Comorbid migraine and insomnia. Migraine and insomnia vs. Healthy controls was evaluated on Functional connectivity (FC) profiles of default mode network (DMN) subnetworks. Patients with comorbid migraine and insomnia exhibited shared functional connectivity alterations in the dorsomedial prefrontal and posteromedial cortex subnetworks compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: