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The aim is to explore how insomnia severity impacts brain connectivity and cognitive functions in major depressive disorder (MDD).

May 13, 2026Psychological MedicineOpen Access

Insomnia severity impact dynamic connectivity and modulate connectivity-cognitive links in major depressive disorder

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The aim is to explore how insomnia severity impacts brain connectivity and cognitive functions in major depressive disorder (MDD).
Analyzed 70 MDD groups based on insomnia severity and compared with 122 health controls.
Utilized Hamilton Depression Rating Scale insomnia subscale for assessment.
Applied independent component analysis and a sliding-window approach for connectivity analysis.
Dynamic analysis showed distinct connectivity states in MDD groups compared to health controls.
HI-MDD had more frequent state I and less of state IV compared to HCs.
Increased default mode network connectivity was observed in both MDD groups in dynamic states.

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Dynamic functional network connectivity reveals altered brain patterns in MDD, suggesting insomnia severity affects cognitive function.

Bao et al. (2026) studied this question.

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