Population
Mouse L cells (resistant to poliovirus infection)
Comparison
Transformation with HeLa cell (human) DNA vs HeLa cells
Design
Preclinical
Authors
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Provides rodent model for poliovirus studies; leaves open clinical translation pending further validation.
Introduction of human DNA encoding the poliovirus receptor into mouse cells successfully confers susceptibility to poliovirus infection.
Mendelsohn et al. (1986) studied this question.
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