Key result
A system dynamics simulation model suggested that combined interventions focusing on aggressive diabetes and hypertension management have the biggest impact on reducing the burden of CKD events.
Why the study?
Randomized trials show CKD outcomes can improve with adequate diabetes and hypertension management, raising questions regarding the impact of aggressive management at the population level.
Does aggressive diabetes and hypertension management reduce the burden of CKD at the population level?
Does aggressive diabetes and hypertension management reduce the burden of CKD at the population level?
A system dynamics simulation model suggests that aggressive management of prehypertension, hypertension, and diabetes can significantly reduce the population-level burden of chronic kidney disease.
Supports targeting diabetes and hypertension to reduce population CKD burden; leaves open prospective validation beyond simulation.
Associated with undesirable clinical outcomes including cardiovascular events, kidney failure, and poor quality of life, Chronic Kidney Disease (CKD) is an emerging noncommunicable disease globally. Treatment costs and CKD complications result in an enormous burden on the healthcare system. Randomized control trials suggest that CKD outcomes can improve if individuals with diabetes and hypertension are adequately managed, raising what‐if questions at the population level. This research aims to explore the impact of aggressive diabetes and hypertension management on CKD outcomes. Based on data from randomized control trials, the Singapore Renal Registry, and the literature, a system dynamics simulation model was developed. Results suggest that the key to reducing the burden of CKD at the population level is identifying and aggressively managing individuals with prehypertension and hypertension to reduce risk of developing CKD events. Combined interventions focusing on aggressive diabetes and hypertension management have the biggest impact on CKD outcomes.
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Ansah et al. (2020) studied Chronic Kidney Disease. Aggressive diabetes and hypertension management was evaluated on CKD outcomes. A system dynamics simulation model suggested that combined interventions focusing on aggressive diabetes and hypertension management have the biggest impact on reducing the burden of CKD events.
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