Testing for interferon-gamma in pericardial effusion accurately identified tuberculous pericarditis, with a pooled sensitivity of 0.97 (95% CI 0.87-0.99) and specificity of 0.99.
Meta-Analysis (n=488)
Does testing for interferon-gamma in pericardial effusion accurately diagnose tuberculous pericarditis in patients with pericardial effusion?
Testing for interferon-gamma in pericardial effusion demonstrates high sensitivity and specificity, making it an adequate test for identifying or ruling out tuberculous pericarditis.
Effect estimate: Sensitivity 0.97 (95% CI 0.87-0.99)
BACKGROUND: Several studies have investigated the diagnostic accuracy of tests of pericardial effusion interferon-gamma for tuberculous pericarditis in patients with pericardial effusion, but the results have varied. The aim of this study was to investigate the diagnostic accuracy of interferon-gamma for tuberculous pericarditis using meta-analysis. METHODS: The PubMed and EMBASE databases were searched to identify studies investigating the diagnostic accuracy of tests for interferon-gamma in pericardial effusion for tuberculous pericarditis. The quality of eligible studies was assessed by the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), and the sensitivities and specificities of interferon-gamma across eligible studies were pooled by a bivariate model. RESULTS: A total of four studies encompassing 488 subjects were included. The pooled sensitivity, specificity, positive and negative likelihood ratios (NLRs) were 0.97 95% confidence interval (CI): 0.87-0.99, 0.99 (95% CI: 0.74-1.00), 187 (95% CI: 3-12,542) and 0.03 (95% CI: 0.01-0.14), respectively. CONCLUSION: Testing for interferon-gamma in cases of pericardial effusion is adequate for identifying or ruling out tuberculous pericarditis.
Liu et al. (Thu,) conducted a meta-analysis in Tuberculous pericarditis (n=488). Interferon-gamma testing was evaluated on Diagnostic accuracy (sensitivity and specificity) (Sensitivity 0.97, 95% CI 0.87-0.99). Testing for interferon-gamma in pericardial effusion accurately identified tuberculous pericarditis, with a pooled sensitivity of 0.97 (95% CI 0.87-0.99) and specificity of 0.99.