Key result
In patients without flow-limiting coronary artery disease, body mass index was the strongest independent predictor of stress myocardial blood flow, while myocardial flow reserve exhibited stable lower reference limits across a wide range of BMI.
Why the study?
To determine key patient factors influencing quantitative MBF and establish lower and upper reference limits for 13N-ammonia PET myocardial perfusion imaging.
Observational (n=784)
No
Answers are grounded in this paper and cite their sources.
In patients without flow-limiting CAD, myocardial blood flow parameters are strongly influenced by BMI, with MFR exhibiting stable lower reference limits across a wide range of BMI.
PURPOSE: To determine the most important patient factors influencing quantitative MBF and to report the lower (LRL) and upper (URL) reference limits for 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). METHODS: Patients who underwent 13N-ammonia PET-MPI were screened, and those with evidence of myocardial ischemia or scar, known cardiomyopathy, impaired left ventricular function, non-response to vasodilators, and those who underwent a stress-rest protocol were excluded. Multiple linear regression analyses were performed to identify independent predictors of rest MBF (rMBF), stress MBF (sMBF), and myocardial flow reserve (MFR), and predictor importance was calculated. Finally, median, LRL, and URL for rMBF, sMBF, and MFR were calculated based on the presence of predictors. RESULTS: ), and median MFR was 3.09 (LRL = 2.11; URL = 4.65). The body mass index (BMI) was the single most important independent predictor of rMBF, sMBF, and MFR (predictor importance of 72%, 87%, and 41%, respectively; standardized β=-0.434, -0.566 and - 0.174, respectively). Additional predictors were sex and hypertension for rMBF, sex for sMBF, and hypertension and CACS for MFR. CONCLUSION: In patients without flow-limiting CAD, MBF is strongly influenced by the patient's habitus, whereby median and reference limits for sMBF and rMBF decrease with increasing BMI. Consequently, MFR exhibits stable lower reference limits across a wide range of BMI and may be considered the most robust quantitative parameter derived from 13N-ammonia PET-MPI.
No takes yet. Share an insight, caveat, or question.
Pingree et al. (2025) conducted an observational in Suspected chronic coronary syndrome without flow-limiting coronary artery disease (n=784). Body mass index (BMI) was evaluated on Stress myocardial blood flow (sMBF) (standardized β=-0.566, p=<0.001). In patients without flow-limiting coronary artery disease, body mass index was the strongest independent predictor of stress myocardial blood flow, while myocardial flow reserve exhibited stable lower reference limits across a wide range of BMI.
Synapse has enriched 10 related papers. Consider them for comparative context: