Key result
Cigarette smoking is linked to ~30% greater carotid IMT compared to non-smokers.
Why the study?
Cigarette smoking contributes to premature atherosclerosis, but the exact mechanism of arterial wall damage remains largely unknown.
Does chronic cigarette smoking increase carotid intima-media thickness and alter carotid hemodynamics in healthy young adults?
Case-Control (n=100)
Yes
Does chronic cigarette smoking increase carotid intima-media thickness and alter carotid hemodynamics in healthy young adults?
Absolute Event Rate: 0.6% vs 0.462%
p-value: p=0.000
Chronic cigarette smoking in healthy young adults is associated with significantly increased carotid intima-media thickness and altered hemodynamics, indicating early subclinical atherosclerosis.
May support vascular risk awareness in young smokers; leaves open whether cessation reverses IMT changes.
Background Cigarette smoking is a causative factor in premature atherosclerosis, but the exact mechanism of smoking-induced damage to the arterial wall and its relationship to the atherosclerotic process are still largely unknown. Carotid ultrasound may help target treatment. The aim of this study was to measure carotid intima-media thickness (IMT) and carotid Doppler parameters in Sudanese smokers compared to non-smokers using ultrasound. Methods This was a retrospective, case–control, community-based study conducted between June 2021 and September 2021. The study was conducted on 100 Sudanese subjects (50 smokers as the case group and 50 non-smokers as the control group). The practical part was conducted in Khartoum State at Al Raqi University Hospital using the E-CUBE 8-ALPINION and at Yastbshroon Hospital using the Fukuda Denshi Sefius UF890AG with a high-frequency linear transducer (7–10 MHz). Scanning was performed in the supine position with the neck extended. Pulsed-wave (PW) Doppler spectral and IMT measurements were obtained. Results The mean age was 29.8 ± 4.5 years (range 24–40 years), and the mean IMT in smokers was 0.6 ± 0.06 mm, which was greater than the mean in non-smokers (0.462 ± 0.09 mm) ( p = 0.000). Peak systolic velocity (PSV) was increased in smokers (40.0 ± 5.67 cm/s) compared to non-smokers (26.5 ± 5.6 cm/s) ( p = 0.000), and end-diastolic velocity (EDV) was decreased in smokers (6.0 ± 1.2 cm/s) compared to non-smokers (9.8 ± 2.2 cm/s) ( p = 0.000). In addition, the resistive index (RI) and the systolic-diastolic ratio (S/D) were not significantly different between smokers and non-smokers. The study showed that there was a significant positive correlation between IMT and the number of cigarettes per day in chronic smokers ( p < 0.05), whereas peak systolic velocity (PSV) and end-diastolic velocity (EDV) were not affected in chronic smokers. Conclusions There was a statistically insignificant difference between the case (smokers) and control (non-smokers) groups in terms of age, body mass index (BMI), resistance index (RI), and systolic–diastolic ratio (S/D). While there were statistically significant differences in intima-media thickness (IMT), peak systolic velocity (PSV), and end-diastolic velocity (EDV), regular follow-up of individuals with a history of smoking is recommended to detect carotid intimal changes earlier.
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Alsiddig et al. (2024) conducted a case-control in Subclinical atherosclerosis (n=100). Cigarette smoking vs. Non-smokers was evaluated on Mean carotid intima-media thickness (IMT) (p=0.000). Cigarette smoking was associated with a significantly greater mean carotid intima-media thickness (0.6 mm) compared to non-smokers (0.462 mm).
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