April 1, 1989The Annual Review of Pharmacology and Toxicology
The Biochemical Pharmacology of Atrial Peptides
Design
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Implication
Details atrial peptide biochemistry; leaves open clinical translation to modern HF therapies.
Key Points
- This work aims to provide a detailed overview of the atrial peptide system and its biochemical properties.
- Schematic framework presentation for atrial peptide analysis
- Characterization of amino acid sequences using cDNA probes
- Isolation and sequencing of unique peptides from rat atrial extracts
- Characterized atrial natriuretic factor (ANF) and related peptides such as ANP and cardionatrin.
- Identified non-atrial biosynthesis sites of atriopeptin during fetal and neonatal development.
- Isolated a novel atriopeptin-like peptide called iso-rANP from rat atrial extracts.
Cite This Study
Needleman et al. (1989) studied this question.