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January 1, 1978Japanese Circulation JournalOpen Access

Storage Form of Renin in the Dog Kidney : VII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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Population

Dog kidney renin granules

Design

Preclinical

Authors

SFSusumu FunakawaShionogi (Japan)KYKenjiro YamamotoTokyo Medical University

Discussion

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Implication

No clinical implications from canine granules; leaves open mediator-dependent renin release mechanisms in humans.

Structured PICO

P
Population
Dog kidney renin granules
I
Intervention
Hypo-osmotic shock, incubation at 37C in isotonic medium, addition of cations, and acidification
O
Outcome
Renin release and molecular weight of stored reninsurrogate

Renin is stored in dog kidney granules as a stable, 43,000 MW form that likely requires cellular mediators rather than just cations for physiological release.

Cite This Study

Funakawa et al. (1978) studied this question.

synapsesocial.com/papers/6a20b9c3300c028f6f39764chttps://doi.org/10.1253/jcj.42.633
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation of Renin Granules from Rat Kidney Cortex and Evidence for an Inactive Form of Renin (Prorenin) in Granules and Plasma1976 · 65 citations
  2. 2A RELEASE OF RENIN FROM DOG KIDNEY CORTEX SLICES1970 · 44 citations
  3. 3Occurrence of Big Renin in Human Plasma, Amniotic Fluid and Kidney Extracts1975 · 138 citations
  4. 4A Protein-Bound Form of Porcine Renal Renin1974 · 123 citations
  5. 5Control of renin secretion in the anesthetized dog1964 · 326 citations