Key result
Right ventricular internal work was the strongest independent predictor of major adverse cardiovascular events (OR 1.00013, p=0.002), whereas right ventricular insertion point late gadolinium enhancement failed to predict outcome.
Why the study?
Do right ventricular internal work and insertion point late gadolinium enhancement predict adverse cardiovascular events in patients with pulmonary hypertension?
Cohort (n=124)
No
Do right ventricular internal work and insertion point late gadolinium enhancement predict adverse cardiovascular events in patients with pulmonary hypertension?
Answers are grounded in this paper and cite their sources.
CMR-derived right ventricular internal mechanical work is a significant predictor of adverse outcomes in pulmonary hypertension, whereas late gadolinium enhancement fails to retain its prognostic value in this specific population.
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Robert W.W. Biederman (2017) conducted a cohort in Pulmonary Hypertension (n=124). Right ventricular internal work and late gadolinium enhancement on cardiac MRI was evaluated on Composite of death, hospitalized RV failure, initiation of parenteral prostacyclin, sustained ventricular arrhythmia or referral for lung transplantation (OR 1.00013, 95% CI 1.000047-1.000213, p=0.002). Right ventricular internal work was the strongest independent predictor of major adverse cardiovascular events (OR 1.00013, p=0.002), whereas right ventricular insertion point late gadolinium enhancement failed to predict outcome.
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