Why the study?
Does captopril prevent cardiovascular remodeling in a rat model of pressure overload cardiac hypertrophy?
Population
Adult male Sprague-Dawley rats with a subdiaphragmatic aortic band
Comparison
Captopril (400 mg/l) for 4 weeks vs Untreated aortic-banded rats, and sham-operated…
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports vascular-selective ACEI effects in rat pressure overload; leaves open dissociation of hypertrophy from fibrosis in humans.
Does captopril prevent cardiovascular remodeling in a rat model of pressure overload cardiac hypertrophy?
In a rat model of pressure overload, captopril prevents vascular and fibrotic changes but does not prevent cardiac hypertrophy, suggesting the renin-angiotensin system mediates vascular remodeling independent of arterial pressure.
Regan et al. (1996) studied this question.
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