Why the study?
Does a potassium- and magnesium-enriched salt alternative improve the cardiovascular effects of ramipril compared to regular salt in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats
Comparison
Ramipril combined with a novel sodium-reduced… vs Ramipril combined with regular salt, or control…
Design
Preclinical
Follow-up
6 weeks
Authors
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May blunt ramipril benefits with regular salt in hypertensive models; hypothesis-generating for salt alternatives, requiring human trials.
Does a potassium- and magnesium-enriched salt alternative improve the cardiovascular effects of ramipril compared to regular salt in stroke-prone spontaneously hypertensive rats?
Replacement of regular salt with a potassium-, magnesium-, and L-lysine-enriched salt alternative preserves the cardiovascular protective effects of ramipril in hypertensive rats.
Mervaala et al. (1994) studied this question.
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