Key result
Abnormal hs-TnT linked to ~4.7-fold higher mortality in psycho-cardiological disease.
Why the study?
The deleterious effects of psychological problems on coronary heart disease are not satisfactorily explained.
What are the independent risk factors for cardiovascular mortality in patients with psycho-cardiological disease?
Retrospective (n=132)
No
What are the independent risk factors for cardiovascular mortality in patients with psycho-cardiological disease?
Hazard Ratio: 4.668 (95% CI 1.293–16.854)
Absolute Event Rate: 32.7% vs 51.3%
p-value: p=0.019
In patients with psycho-cardiological disease, elevated total cholesterol, hs-troponin T, and prior percutaneous coronary intervention are independent risk factors for cardiovascular mortality.
hs-TnT may stratify mortality risk in psycho-cardiological disease; leaves open whether targeted interventions improve outcomes.
OBJECTIVES: The deleterious effects of psychological problems on coronary heart disease (CHD) are not satisfactorily explained. We explored influential factors associated with mortality in psycho-cardiological disease in a Chinese sample. METHODS: Of 7460 cardiac patients, we selected 132 patients with CHD and mental illness. Follow-up was conducted via telephone. We analyzed clinical characteristics, clinical outcomes, and survival. RESULTS: The clinical detection rate of psycho-cardiological disease in the overall patient population was 1.8%. Of these, 113 patients completed follow-up; 18 died owing to cardiovascular diseases during follow-up. Kaplan-Meier analysis showed dysphagia, limb function, self-care ability, percutaneous coronary intervention, low-density lipoprotein, total cholesterol, pro-brain natriuretic peptide and high-sensitivity (hs) troponin T had significant associations with cumulative survival. Cox regression analysis showed total cholesterol (hazard ratio [HR]: 2.765, 95% confidence interval [CI]: 1.001-7.641), hs troponin T (HR: 4.668, 95% CI: 1.293-16.854), and percutaneous coronary intervention (HR: 3.619, 95% CI: 1.383-9.474) were independently associated with cumulative survival. CONCLUSIONS: The clinical detection rate of psycho-cardiological disease was far lower than expected. Normal total cholesterol and hs troponin T were associated with reduced cardiovascular disease mortality over 2 years. Percutaneous coronary intervention is a prognostic risk factor in patients with psycho-cardiological disease.
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Minhua et al. (2021) conducted a retrospective in Coronary heart disease and mental illness (anxiety or depression) (n=132). Abnormal high-sensitivity troponin T (hs-TnT) vs. Normal hs-TnT was evaluated on Cumulative survival (cardiovascular disease mortality) (HR 4.668, 95% CI 1.293-16.854, p=0.019). Abnormal high-sensitivity troponin T (hs-TnT) was independently associated with a significantly increased risk of mortality (HR 4.668) in patients with psycho-cardiological disease.
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