Key result
Depression in PAD is linked to ~24% higher mortality, plus increased amputation and functional decline.
Why the study?
Depression frequently coexists with peripheral artery disease and is linked to adverse outcomes, but a comprehensive summary of its prevalence, clinical impact, and underlying mechanisms was needed.
Does depression worsen clinical outcomes such as mortality, amputation, and functional decline in patients with peripheral artery disease?
Does depression worsen clinical outcomes such as mortality, amputation, and functional decline in patients with peripheral artery disease?
Answers are grounded in this paper and cite their sources.
Depression is a highly prevalent comorbidity in peripheral artery disease that significantly increases the risk of mortality, amputation, and functional decline, highlighting the need for routine screening and integrated management.
Peripheral artery disease is a chronic vascular disorder associated with substantial morbidity, mortality, and functional decline. Depression frequently coexists with this condition and is consistently linked to adverse outcomes, including increased risk of limb loss, higher mortality, reduced adherence to therapy, and diminished benefits from revascularization procedures. This narrative review summarizes the current evidence on the prevalence of depression among patients with peripheral artery disease, its impact on clinical outcomes, and the biological and behavioral mechanisms that may explain this association. The findings emphasize the importance of recognizing depression as a major determinant of prognosis in peripheral artery disease and support systematic screening and integrated management as essential components of comprehensive patient care.
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Giosdekos et al. (2025) conducted a review in Peripheral Artery Disease. Depression vs. No depression was evaluated on All-cause mortality (HR 1.24, 95% CI 1.07-1.25). Depression is prevalent in approximately 24-25% of patients with peripheral artery disease and is associated with a 24% increased risk of all-cause mortality, as well as higher risks of amputation and functional decline.
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