Why the study?
The systemic laboratory abnormalities accompanying documented heart failure in patients hospitalized with severe MR had not been fully characterized across multiple biological domains within the same cohort.
Are systemic laboratory alterations, such as reduced eGFR, associated with concomitant heart failure in hospitalized patients with severe mitral regurgitation?
Cross-Sectional (n=107)
No
Are systemic laboratory alterations, such as reduced eGFR, associated with concomitant heart failure in hospitalized patients with severe mitral regurgitation?
Answers are grounded in this paper and cite their sources.
In hospitalized patients with severe mitral regurgitation, renal dysfunction (eGFR <60 mL/min/1.73 m²) shows the strongest independent association with concomitant heart failure among multiple laboratory domains.
Background: The systemic laboratory abnormalities accompanying documented heart failure in patients hospitalized with severe mitral regurgitation (MR) have not been fully characterized across multiple biological domains within the same cohort. Methodology: In this retrospective, single-center, cross-sectional study, 107 adults with echocardiographically documented severe MR were compared according to the presence (*n* = 49) or absence (*n* = 58) of a heart failure diagnosis at discharge. Results: Multiple laboratory domains differed by heart failure status. In the post hoc integrated model, eGFR <60 mL/min/1.73 m² showed the most consistent association with concomitant heart failure (odds ratio, 5.56; 95% confidence interval, 1.94-15.94; *P* = 0.001); C-reactive protein and anemia were not statistically significant after mutual adjustment. The apparent and optimism-corrected areas under the curve were 0.809 and 0.780, respectively; corresponding Brier scores were 0.175 and 0.196. Conclusions: Among hospitalized patients with severe MR, documented concomitant heart failure was accompanied by abnormalities across several laboratory domains, with reduced renal function showing the most consistent association in exploratory multivariable analyses.
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Fiat et al. (2026) conducted a cross-sectional in Severe mitral regurgitation (n=107). Reduced renal function (eGFR <60 mL/min/1.73 m²) and systemic laboratory alterations vs. Normal/preserved laboratory values or absence of heart failure diagnosis at discharge was evaluated on Concomitant heart failure diagnosis at discharge (OR 5.56, 95% CI 1.94-15.94, p=0.001).
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