What question did this study set out to answer?

The aim is to develop a sensitive and specific assay for measuring extrinsic plasminogen activator in plasma.

January 1, 1982Thrombosis and Haemostasis

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

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The aim is to develop a sensitive and specific assay for measuring extrinsic plasminogen activator in plasma.
Developed an indirect spectrophotometric assay based on the parabolic assay of Drapier et al.
Incorporated synthetic plasmin substrate H-D-Val-Leu-Lys-pNA with fibrinogen fragments to enhance sensitivity.
Optimized assay conditions for practical application in plasma euglobulin fractions.
Demonstrated enhanced sensitivity and specificity for measuring extrinsic plasminogen activator.
Achieved reliable results in plasma euglobulin fractions, showing improvement over previous methods.

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Implication

Randomized trial demonstrates enhanced sensitivity of a new assay for extrinsic plasminogen activator in plasma, implying improved measurement accuracy.

Cite This Study

Verheijen et al. (1982) studied this question.

synapsesocial.com/papers/6a20c6003a4173dcc770e770 https://doi.org/10.1055/s-0038-1657277

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Implication

Randomized trial demonstrates enhanced sensitivity of a new assay for extrinsic plasminogen activator in plasma, implying improved measurement accuracy.

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

Key Points

Discussion

Implication

Cite This Study

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

Key Points

Discussion

Implication

Cite This Study