s geriatric clinical pharmacology undergoes maturation, it will be necessary to move be-yond a focus on elucidating simple pharmacokinetic differences between young and old and the atten-dant assumption that differences in response are solely due to differences in drug concentration. The complexity and inaccessibility of the central nervous system make this advance a somewhat daunting prospect. Problems include controlling for age-re-lated pharmacokinetic differences as well as their interaction with age-related changes in neurotrans-mitters, receptors, and neuropsychological function. Nonetheless, the search for tests of individual phar-macodynamic response and the accumulation of
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Pollock et al. (1990) studied this question.
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