Key result
Aerobic exercise training induces beneficial skeletal muscle adaptations, including reduced inflammation, improved anabolic processes, decreased hypoxia, and enhanced mitochondrial function in patients with pulmonary arterial hypertension.
Why the study?
The mechanisms underlying the therapeutic potential of aerobic exercise on skeletal muscle dysfunctions in patients with pulmonary arterial hypertension remain poorly understood.
Does aerobic exercise training improve skeletal muscle dysfunctions in patients with pulmonary arterial hypertension?
Does aerobic exercise training improve skeletal muscle dysfunctions in patients with pulmonary arterial hypertension?
Aerobic exercise training is a promising non-pharmacological therapy that may mitigate skeletal muscle myopathy and improve exercise tolerance in patients with pulmonary arterial hypertension through multiple cellular and molecular pathways.
Hypothesis-generating for aerobic exercise in PAH muscle dysfunction; randomized trials needed before practice change.
Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. Aerobic physical training induces skeletal muscle adaptations via reduced inflammation, improved anabolic processes, decreased hypoxia and regulation of mitochondrial function. These benefits improve physical exertion tolerance and quality of life in patients with pulmonary arterial hypertension. However, the mechanisms underlying the therapeutic potential of aerobic exercise to skeletal muscle disfunctions in patients with pulmonary arterial hypertension are not well understood yet. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension.
No takes yet. Share an insight, caveat, or question.
Drummond et al. (2023) conducted a review in Pulmonary arterial hypertension. Aerobic exercise training was evaluated. Aerobic exercise training induces beneficial skeletal muscle adaptations, including reduced inflammation, improved anabolic processes, decreased hypoxia, and enhanced mitochondrial function in patients with pulmonary arterial hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: