Key result
Male bariatric candidates carry ~18 percentage points higher prevalence of moderate-to-severe steatosis than females.
Why the study?
The study aimed to evaluate gender differences and steatosis status within gender groups in a cohort of patients with obesity.
Cohort (n=250)
No
Absolute Event Rate: 85.2% vs 66.7%
p-value: p=0.006
There are significant gender-based differences in clinical and hematological parameters, as well as liver steatosis prevalence, among obese patients undergoing bariatric surgery.
May support sex-specific steatosis risk assessment in bariatric candidates; leaves open whether this alters management or outcomes.
Background: Obesity is a major public health problem worldwide. Bariatric surgery can reduce body weight, and it is one of the better ways to improve metabolic disease and lifestyle. The aim of this study was to explore a new cohort of patients with obesity and evaluate the gender differences and the steatosis status within the gender group. Methods: A cohort of 250 adult obese patients with BMI ≥ 30 and age >18 years, eligible for gastric bariatric surgery at Pineta Grande Hospital, Castel Volturno (Italy) was studied. Results: The prevalence in women was higher (72.40%) than men (27.60%). Overall, results indicated many statistically significant gender differences in hematological and clinical parameters. Analysis of the subcohorts based on the severity of steatosis revealed differences of this condition between the genders. Steatosis was more prevalent in the male subcohort, but female patients revealed greater within-group differences. Conclusions: Many differences were found not only in the total cohort but also between the gender subcohorts, both in the presence and absence of steatosis. We can conclude that the pathophysiological, genetic, and hormonal patterns affecting these patients delineate different individual profiles.
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Donghia et al. (2023) conducted a cohort in Obesity (n=250). Male gender vs. Female gender was evaluated on Prevalence of moderate/severe liver steatosis (p=0.006). Male obese patients eligible for bariatric surgery exhibited a significantly higher prevalence of moderate to severe liver steatosis compared to female patients (85.2% vs. 66.7%, p=0.006).
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