Therapy of Locally Recurrent Renal Cell Carcinoma After Nephrectomy

No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1996Therapy of Locally Recurrent Renal Cell Carcinoma After Nephrectomy Simon Tanguay, Louis L. Pisters, David D. Lawrence, and Colin P.N. Dinney Simon TanguaySimon Tanguay , Louis L. PistersLouis L. Pisters , David D. LawrenceDavid D. Lawrence , and Colin P.N. DinneyColin P.N. Dinney View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66529-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the outcome of patients with locally recurrent renal cell carcinoma treated at our university. Materials and Methods: We retrospectively analyzed 16 cases of locally recurrent renal cell carcinoma in the renal fossa treated with surgical resection alone or in combination with biological therapy. Results: Complete resection was possible in 15 patients of whom 3 had positive surgical margins. Of the 12 patients with negative margins 6 are free of disease while the 3 with positive margins had involvement of a remaining ipsilateral adrenal gland and distant metastasis. Of all 16 patients 12 are alive a median of 23.5 months after the diagnosis of locally recurrent renal cell carcinoma. Of those treated with the combination of biological therapy and surgery 50 percent have no evidence of disease compared to 25 percent of those treated with surgery alone. Conclusions: Long-term survival can be achieved with an aggressive surgical approach. Incomplete resection or positive surgical margins are associated with a high risk of local or distant failure, and combined treatment with immunotherapy and surgery may offer a benefit compared to surgery alone. References 1 : The natural history of metastatic renal cell carcinoma: a computer analysis. J. Urol.1978; 120: 148. Link, Google Scholar 2 : Experience with fossa recurrence of renal cell carcinoma. J. Urol.1992; 147: 1491. Link, Google Scholar 3 : Preoperative external beam radiotherapy followed by cytoreductive surgery and intraoperative radiotherapy for locally advanced primary or recurrent renal malignancies. J. Urol.1994; 152: 15. Abstract, Google Scholar 4 : TNM Classification of Malignant Tumours. In: . Edited by . Berlin: Springer-Verlag1987. Google Scholar 5 : Factors influencing adrenal metastasis in renal carcinoma. J. Urol.1994; 151: 1181. Abstract, Google Scholar 6 : Surgery following response to interferon-alpha-based therapy for residual renal cell carcinoma. J. Urol.1993; 149: 19. Link, Google Scholar 7 : Surgical resection following interleukin 2 therapy for metastatic renal cell carcinoma prolongs remission. Arch. Surg.1992; 127: 1343. Google Scholar 8 : Surgical resection of metastatic renal cell carcinoma and melanoma after response to interleukin-2-based immunotherapy. Cancer1992; 69: 1850. Google Scholar Departments of Urology and Diagnostic Imaging, University of Texas M. D. Anderson Cancer Center, Houston, Texas.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byThomas A, Adibi M, Borregales L, Hoang L, Tamboli P, Jonasch E, Tannir N, Matin S, Wood C and Karam J (2015) Surgical Management of Local Retroperitoneal Recurrence of Renal Cell Carcinoma after Radical NephrectomyJournal of Urology, VOL. 194, NO. 2, (316-322), Online publication date: 1-Aug-2015.de Martino M, Pantuck A, Hofbauer S, Waldert M, Shariat S, Belldegrun A and Klatte T (2013) Prognostic Impact of Preoperative Neutrophil-to-Lymphocyte Ratio in Localized Nonclear Cell Renal Cell CarcinomaJournal of Urology, VOL. 190, NO. 6, (1999-2004), Online publication date: 1-Dec-2013.Margulis V, McDonald M, Tamboli P, Swanson D and Wood C (2009) Predictors of Oncological Outcome After Resection of Locally Recurrent Renal Cell CarcinomaJournal of Urology, VOL. 181, NO. 5, (2044-2051), Online publication date: 1-May-2009.Boorjian S, Crispen P, Lohse C, Leibovich B and Blute M (2008) Surgical Resection of Isolated Retroperitoneal Lymph Node Recurrence of Renal Cell Carcinoma Following NephrectomyJournal of Urology, VOL. 180, NO. 1, (99-103), Online publication date: 1-Jul-2008.MASTER V, GOTTSCHALK A, KANE C and CARROLL P (2018) MANAGEMENT OF ISOLATED RENAL FOSSA RECURRENCE FOLLOWING RADICAL NEPHRECTOMYJournal of Urology, VOL. 174, NO. 2, (473-477), Online publication date: 1-Aug-2005.STEPHENSON A, CHETNER M, ROURKE K, GLEAVE M, SIGNAEVSKY M, PALMER B, KUAN J, BROCK G and TANGUAY S (2018) GUIDELINES FOR THE SURVEILLANCE OF LOCALIZED RENAL CELL CARCINOMA BASED ON THE PATTERNS OF RELAPSE AFTER NEPHRECTOMYJournal of Urology, VOL. 172, NO. 1, (58-62), Online publication date: 1-Jul-2004.FRANK I, BLUTE M, CHEVILLE J, LOHSE C, WEAVER A, LEIBOVICH B and ZINCKE H (2018) A Multifactorial Postoperative Surveillance Model for Patients With Surgically Treated Clear Cell Renal Cell CarcinomaJournal of Urology, VOL. 170, NO. 6, (2225-2232), Online publication date: 1-Dec-2003.Schrödter S, Hakenberg O, Manseck A, Leike S and Wirth M (2018) Outcome Of Surgical Treatment Of Isolated Local Recurrence After Radical Nephrectomy For Renal Cell CarcinomaJournal of Urology, VOL. 167, NO. 4, (1630-1633), Online publication date: 1-Apr-2002.ITANO N, BLUTE M, SPOTTS B and ZINCKE H (2018) OUTCOME OF ISOLATED RENAL CELL CARCINOMA FOSSA RECURRENCE AFTER NEPHRECTOMYJournal of Urology, VOL. 164, NO. 2, (322-325), Online publication date: 1-Aug-2000.SLATON J, SWANSON D, GROSSMAN H and DINNEY C (2018) A STAGE SPECIFIC APPROACH TO TUMOR SURVEILLANCE AFTER RADICAL CYSTECTOMY FOR TRANSITIONAL CELL CARCINOMA OF THE BLADDERJournal of Urology, VOL. 162, NO. 3 Part 1, (710-714), Online publication date: 1-Sep-1999.LEVY D, SLATON J, SWANSON D and DINNEY C (2018) STAGE SPECIFIC GUIDELINES FOR SURVEILLANCE AFTER RADICAL NEPHRECTOMY FOR LOCAL RENAL CELL CARCINOMAJournal of Urology, VOL. 159, NO. 4, (1163-1167), Online publication date: 1-Apr-1998. Volume 155Issue 1January 1996Page: 26-29 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Simon Tanguay More articles by this author Louis L. Pisters More articles by this author David D. Lawrence More articles by this author Colin P.N. Dinney More articles by this author Expand All Advertisement PDF downloadLoading ...