Key result
68Ga-FAPi PET/CT shows preliminary potential to detect active myocardial fibrosis and assess disease progression.
Why the study?
Fibroblast activation protein inhibitor PET has gained interest for detecting myocardial fibrosis, distinguishing active from chronic disease, and evaluating disease progression and treatment response.
Does FAPi PET/CT imaging accurately detect active myocardial fibrosis and predict ventricular remodeling in cardiovascular diseases?
Does FAPi PET/CT imaging accurately detect active myocardial fibrosis and predict ventricular remodeling in cardiovascular diseases?
FAPi PET/CT is an emerging molecular imaging modality that can noninvasively detect active myocardial fibrosis, offering potential prognostic value for ventricular remodeling in cardiovascular diseases.
May support noninvasive active fibrosis imaging; leaves open prospective validation before clinical adoption.
Purpose of Review Myocardial fibrosis is a response to myocardial injury and plays a pivotal role in ventricular remodeling. Different patterns of fibrosis are associated with different disease states, but the presence and amount of fibrosis provide a different impact on prognosis. Recent Findings In the latest years, fibroblast activation protein inhibitor (FAPi) positron emission tomography (PET) gain interest for its potential in detecting myocardial fibrosis, in differentiating between active and chronic disease, and in the assessment of disease progression and response to treatment. Summary We aim to highlight the most relevant current applications of FAPi PET/CT in cardiovascular imaging, focusing on its applications, advantages, limitations, and to underline future clinical perspective.
No takes yet. Share an insight, caveat, or question.
Popescu et al. (2023) conducted a review in Cardiovascular diseases (myocardial fibrosis, myocardial infarction, heart failure). 68Ga-FAPi PET/CT was evaluated. 68Ga-FAPi PET/CT demonstrates potential in detecting active myocardial fibrosis and assessing disease progression across various cardiovascular conditions, though current evidence remains preliminary.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: