Why the study?
Does propranolol affect coronary blood flow and resistance in open-chest anaesthetized dogs?
Does propranolol affect coronary blood flow and resistance in open-chest anaesthetized dogs?
Propranolol reduces coronary blood flow and increases coronary resistance in a canine model, likely secondary to decreased myocardial oxygen consumption from reduced left ventricular work.
Warrants caution extrapolating canine coronary effects to patients; leaves open beta-blocker impact on human coronary resistance.
Propranolol caused a reduction of left circumflex coronary blood flow and increased coronary resistance in open-chest anaesthetized dogs. Similar results were shown at rest and during exercise produced by repetitive electrical stimulation of the leg muscles. Diminished coronary flow occurred in association with diminished left ventricular work and a diminished product of arterial mean pressure and heart rate. This suggests that myocardial oxygen consumption decreased and may have been responsible for the diminished coronary flow.
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Stein et al. (1968) studied this question.
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