Population
Bovine cardiac troponin T (isoforms TnT1, TnT2, and chemically cleaved TnT 39-284)
Comparison
Reconstitution of troponins with troponin I and… vs Comparison among the three reconstituted troponins
Design
Preclinical
Authors
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No immediate clinical implications from this animal study; extends mechanistic understanding of cardiac TnT domain functions.
The amino-terminal region of cardiac TnT modulates the interaction of Ca2+ with troponin and the thin filament, while its effects on tropomyosin binding are due to the carboxyl-terminal portion.
Larry S. Tobacman (1988) studied this question.
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