Calponin and troponin T bind to a highly conserved domain on smooth muscle tropomyosin, suggesting calponin may play a role in regulating the contractile apparatus.
Hypothesis-generating for calponin in smooth muscle regulation; leaves open translational relevance to hypertension.
Calponin is a smooth muscle tropomyosin-binding protein which is antigenically related to troponin T. The fine localization of calponin and troponin T on the polar paracrystals of smooth muscle tropomyosin were studied by electron microscopy. Both calponin and troponin T bound to the filamentous tropomyosin at a site about 17 nm away from the C-terminal end of tropomyosin molecule. This calponin-binding site corresponds to the domain which is highly conserved in the amino-acid sequences among the tropomyosin isoforms from skeletal muscle and smooth muscle. The result suggests that calponin, in collaboration with tropomyosin, may play an important role in regulating contractile apparatus.
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Takahashi et al. (1988) studied this question.
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