Key result
Gene transfer of eNOS restored endothelium-dependent relaxation to acetylcholine in aortas from angiotensin II-infused rabbits (82% vs 67% with control virus).
Why the study?
Does gene transfer of eNOS or SOD improve vasomotor function in aortas from angiotensin II-treated rabbits?
Does gene transfer of eNOS or SOD improve vasomotor function in aortas from angiotensin II-treated rabbits?
Absolute Event Rate: 82% vs 67%
Gene transfer of eNOS, but not SOD, effectively restores vasomotor function in an animal model of angiotensin II-induced endothelial dysfunction.
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Does not inform clinical hypertension management; extends preclinical eNOS gene transfer data but leaves human translation open.
Nakane et al. (2000) studied Angiotensin II-induced endothelial dysfunction. Gene transfer of eNOS (AdeNOS) vs. Adenovirus containing beta-gal (Adbeta-gal) was evaluated on Maximal relaxation to acetylcholine. Gene transfer of eNOS restored endothelium-dependent relaxation to acetylcholine in aortas from angiotensin II-infused rabbits (82% vs 67% with control virus).
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