Key result
Among Sudanese males, serum adiponectin was significantly lower in patients with type 2 diabetes compared to healthy controls (3.03 vs 6.02 µg/ml, P≤0.000) and correlated negatively with HOMA-IR.
Why the study?
Diabetes and its complications are a primary cause of global morbidity and mortality, prompting investigation into the relationship between serum adiponectin and insulin resistance in Sudanese males with type 2 diabetes mellitus.
Is serum adiponectin associated with insulin resistance in Sudanese males with Type 2 Diabetes Mellitus?
Case-Control (n=252)
No
Is serum adiponectin associated with insulin resistance in Sudanese males with Type 2 Diabetes Mellitus?
Absolute Event Rate: 3.03% vs 6.02%
p-value: p=≤ 0.000
Low plasma adiponectin levels are significantly associated with insulin resistance in Sudanese males with Type 2 Diabetes Mellitus.
Should not yet change practice in Sudanese males with T2DM; hypothesis-generating for adiponectin as insulin resistance marker in African populations.
Background: Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increased mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide. Aims and objectives: The aim of this study was to correlate serum levels of adiponectin with insulin resistance in Sudanese males' type 2 diabetes mellitus. Design and Methods: A case-control community-based study carried out among 126 patients with T2DM as cases group (mean ages 45.2±5.4 years); and 126 normal healthy individuals as controls group (mean ages 44.7±5.4 years as) in Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL of fasting venous blood was obtained from all participants. HbA1c, FPG, FPI, serum Adiponectin, and (HOMA)- IR were analyzed. SPSS (v 20.0) was used for data analysis. Results: The mean of serum adiponectin in the cases group (3.03±0.90µg/ml) was lower than the control group (6.02±4.24µg/ml) giving highly significant differences -between them (P=value ≤ 0.000). HbA1c and Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) differed significantly between the two groups (P-value ≤ 0.000). Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002). Conclusion: We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males.
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Almakey et al. (2021) conducted a case-control in Type 2 diabetes mellitus (n=252). Type 2 diabetes mellitus vs. Normal healthy individuals was evaluated on Serum adiponectin concentration (p=≤ 0.000). Among Sudanese males, serum adiponectin was significantly lower in patients with type 2 diabetes compared to healthy controls (3.03 vs 6.02 µg/ml, P≤0.000) and correlated negatively with HOMA-IR.
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