Key result
Angiotensin II and nitric oxide signaling pathways mutually regulate each other, and their balance is critical for normal vascular structure and function.
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The balance between Angiotensin II and nitric oxide signaling pathways is critical for normal vascular function, and its disruption is implicated in vascular diseases.
Angiotensin II (Ang II) and nitric oxide (NO) signaling pathways mutually regulate each other by multiple mechanisms. Ang II regulates the expression of NO synthase and NO production, whereas NO downregulates the Ang II type I (AT1) receptor. In addition, downstream effectors of Ang II and NO signaling pathways also interact with each other. A feedback mechanism between Ang II and NO is critical for normal vascular structure and function. Imbalance of Ang II and NO has been implicated in the pathophysiology of many vascular diseases. In this review, we focus on the diverse ways in which Ang II and NO interact and the importance of the balance between the signaling pathways activated by these mediators.
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Chen et al. (2003) conducted a review in Vascular diseases. Angiotensin II and Nitric Oxide was evaluated. Angiotensin II and nitric oxide signaling pathways mutually regulate each other, and their balance is critical for normal vascular structure and function.
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