Key result
Individuals at clinical high risk for psychosis exhibited a significantly increased resting heart rate compared to healthy controls, independent of medication and psychopathological comorbidity.
Why the study?
Autonomic alterations are well documented in schizophrenia, but whether these dysfunctions extend into the clinical high-risk state remains unclear.
Do resting heart rate and heart rate variability differ in individuals at clinical high risk for psychosis compared to healthy controls and clinical controls?
Population
117 CHR-P participants, 38 CHR-N participants, and 49 healthy controls
Comparison
CHR-P participants vs CHR-N participants vs healthy controls
Design
Cross-sectional comparative study
Authors
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May signal autonomic dysfunction in clinical high-risk psychosis; hypothesis-generating and requires prospective validation before any clinical use.
Cross-Sectional (n=204)
No
Do resting heart rate and heart rate variability differ in individuals at clinical high risk for psychosis compared to healthy controls and clinical controls?
Effect estimate: η2 0.19 (95% CI -0.01, 0.08)
Absolute Event Rate: 71.63% vs 67.16%
p-value: p=0.050
Individuals at clinical high risk for psychosis exhibit altered autonomic functioning characterized by an increased resting heart rate, which correlates with subthreshold psychotic symptoms and distress.
Kocsis et al. (2020) conducted a cross-sectional in Clinical High Risk for Psychosis (n=204). Clinical high risk for psychosis (CHR-P) vs. Healthy controls and clinical high-risk negative (CHR-N) individuals was evaluated on Resting heart rate (RHR) (η2 0.19, 95% CI -0.01, 0.08, p=0.050). Individuals at clinical high risk for psychosis exhibited a significantly increased resting heart rate compared to healthy controls, independent of medication and psychopathological comorbidity.
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