Key result
Increased arterial stiffness, assessed by the Cardio-Ankle Vascular Index, was an independent predictor of aortic valve sclerosis (OR 2.048) in asymptomatic individuals without known cardiovascular disease.
Why the study?
Both aortic valve sclerosis and arterial stiffness are linked to atherosclerosis, but their relationship required evaluation in asymptomatic individuals without known cardiovascular disease.
Is increased arterial stiffness (measured by CAVI) associated with aortic valve sclerosis in asymptomatic patients without known cardiovascular disease?
Cross-Sectional (n=165)
No
Is increased arterial stiffness (measured by CAVI) associated with aortic valve sclerosis in asymptomatic patients without known cardiovascular disease?
Odds Ratio: 2.048 (95% CI 1.183–3.547)
p-value: p=0.010
In asymptomatic individuals without known cardiovascular disease, increased arterial stiffness measured by CAVI is independently associated with the presence of aortic valve sclerosis.
Supports further investigation of arterial stiffness in valvular disease; does not yet justify routine CAVI use in asymptomatic patients.
Objectives: This study aimed to examine the relationship between aortic valve sclerosis (AVS) and arterial stiffness in asymptomatic individuals without known cardiovascular (CV) disease.Both AVS and arterial stiffness are associated with atherosclerosis and have been closely related to CV diseases in previous studies. In this study, we aimed to examine the relationship between arterial stiffness assessed by CAVI and AVS. Methods: Patients who applied to the cardiology outpatient clinic were included in the study sequentially. Subjects were analyzed according to exclusion criteria.One hundred sixty-five patients were included in the study, and AVS was detected in 35 (21%) of them. The remaining 130 (79%) patients were included in the control group.AVS was measured with echocardiography, and arterial stiffness was measured with the VaSera VS-1000 CAVI device. A CAVI value of 9 and above was accepted as abnormal. Statistics were made according to the group with and without AVS. Results: CAVI was statistically different between the AVS and control groups(9.47±1.64 vs. 7.60±1.27 p< 0.001). The Pearson correlation test determined the correlation between AVS and increased CAVI values (p< 0.001).In the multivariable logistic regression analysis model, increased CAVI (OR: 2.048, 95%CI 1.183-3.547, p: 0.010) was an independent predictor for AVS.Others were found as age (p:0.026) and diabetes mellitus (p:0.037). Conclusions: The relationship between AVS and arterial stiffness is associated with the atherosclerotic process.Careful investigation and regular follow-up of asymptomatic individuals with AVS detected during echocardiography or increased CAVI values are important in other CV diseases.
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Akyüz et al. (2023) conducted a cross-sectional in Aortic Valve Sclerosis (n=165). Increased Cardio-Ankle Vascular Index (CAVI) vs. Lower CAVI was evaluated on Aortic Valve Sclerosis (OR 2.048, 95% CI 1.183-3.547, p=0.010). Increased arterial stiffness, assessed by the Cardio-Ankle Vascular Index, was an independent predictor of aortic valve sclerosis (OR 2.048) in asymptomatic individuals without known cardiovascular disease.
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