Key result
Among patients with nondialysis CKD, aortic stenosis increased mortality (P<0.001), and lower eGFR further increased all-cause mortality risk (HR 1.18; 95% CI 1.08-1.29 per 10 mL/min/1.73 m2).
Why the study?
The authors sought to study longer term survival in patients with aortic stenosis and nondialysis chronic kidney disease.
Does the presence of aortic stenosis increase mortality in patients with nondialysis chronic kidney disease?
Cohort (n=839)
Does the presence of aortic stenosis increase mortality in patients with nondialysis chronic kidney disease?
Hazard Ratio: 1.18 (95% CI 1.08–1.29)
In patients with nondialysis CKD, concomitant aortic stenosis significantly increases mortality, while aortic valve replacement is associated with improved survival and renal function.
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AS presence may support closer monitoring in nondialysis CKD; leaves open optimal management strategies pending randomized data.
Patel et al. (2019) conducted a cohort in Aortic stenosis and chronic kidney disease (n=839). Lower estimated glomerular filtration rate (per 10 mL/min/1.73 m2) vs. Higher estimated glomerular filtration rate was evaluated on All-cause mortality (HR 1.18, 95% CI 1.08-1.29). Among patients with nondialysis CKD, aortic stenosis increased mortality (P<0.001), and lower eGFR further increased all-cause mortality risk (HR 1.18; 95% CI 1.08-1.29 per 10 mL/min/1.73 m2).
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