Key result
The minor allele of rs7164338 in the CIB2 gene was significantly associated with lower pulse wave velocity (β = -0.359, P = 4.8 x 10^-8) and increased CIB2 expression.
Observational (n=1,505)
Effect estimate: β = -0.359
p-value: p=4.8 x 10^-8
The study identifies the CIB2 gene variant rs7164338 as a novel genetic factor associated with reduced arterial stiffness, potentially through regulation of intracellular calcium and prevention of vascular calcification.
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CIB2 variant may influence arterial stiffness; hypothesis-generating and requires causal validation before clinical consideration.
Mangino et al. (2015) conducted an observational in Healthy (arterial stiffness) (n=1,505). rs7164338 minor allele (C) in the CIB2 gene vs. Major allele (non-carriers) was evaluated on Carotid-femoral pulse wave velocity (PWV) (β = -0.359, p=4.8 x 10^-8). The minor allele of rs7164338 in the CIB2 gene was significantly associated with lower pulse wave velocity (β = -0.359, P = 4.8 x 10^-8) and increased CIB2 expression.
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