Key result
IL-1beta acts as a transcriptional activator of the human BNP promoter in cardiac myocytes through Ras- and Rac-dependent pathways, and partially via p38 kinase targeting the M-CAT element.
Population
Neonatal rat ventricular myocytes transfected with hBNP promoter coupled to a luciferase reporter gene or…
Comparison
IL-1beta treatment for 24 hours, with or without… vs Untreated cells or cells without specific…
Design
Preclinical
Follow-up
24 hours
Authors
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Hypothesis-generating for IL-1β-BNP signaling in myocytes; leaves open whether pathway targeting alters human HF outcomes.
IL-1beta activates the human BNP promoter in cardiac myocytes via Ras-, Rac-, and p38 kinase-dependent pathways, providing mechanistic insight into BNP regulation in infarcted myocardium.
He et al. (1999) studied this question. Interleukin-1beta (IL-1beta) was evaluated on hBNP luciferase activity. IL-1beta acts as a transcriptional activator of the human BNP promoter in cardiac myocytes through Ras- and Rac-dependent pathways, and partially via p38 kinase targeting the M-CAT element.
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