March 1, 1997Journal of Biological ChemistryOpen Access

Differential Effects of Protein Kinase C, Ras, and Raf-1 Kinase on the Induction of the Cardiac B-type Natriuretic Peptide Gene through a Critical Promoter-proximal M-CAT Element

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Population

Neonatal rat ventricular myocytes

Design

Preclinical

Authors

DTDonna J. ThueraufSan Diego State University CGChristopher C. GlembotskiHeart Failure & Transplant

Discussion

Member takes

Implication

Caution against clinical extrapolation from rodent BNP promoter data; leaves open Ras/Raf pathway targeting in human cardiac research.

Structured PICO

Population

Neonatal rat ventricular myocytes

Intervention

Transfection with BNP reporter constructs and expression of constitutively active Ras, Raf-1 kinase, and protein kinase C

Outcome

BNP reporter expression and transcriptionsurrogate

The study identifies a critical promoter-proximal M-CAT element essential for the induction of the cardiac BNP gene via Ras-dependent, Raf-1-independent pathways.

Cite This Study

Thuerauf et al. (1997) studied this question.

synapsesocial.com/papers/6a73126c542cb04b60cd5b67 https://doi.org/10.1074/jbc.272.11.7464

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Differential Effects of Protein Kinase C, Ras, and Raf-1 Kinase on the Induction of the Cardiac B-type Natriuretic Peptide Gene through a Critical Promoter-proximal M-CAT Element

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential Effects of Protein Kinase C, Ras, and Raf-1 Kinase on the Induction of the Cardiac B-type Natriuretic Peptide Gene through a Critical Promoter-proximal M-CAT Element

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider