Key result
Preceding pulmonary hypertension was not associated with event survival (70% vs 65%; adjusted OR 1.30; 95% CI 0.25-6.69; p=0.77) in children with in-hospital cardiac arrest.
Why the study?
Pulmonary hypertension worsens outcomes in adult in-hospital cardiac arrest, but pulmonary hypertension-associated in-hospital cardiac arrest has not been well studied in children.
Does the presence of pulmonary hypertension impact survival outcomes in children experiencing in-hospital cardiac arrest?
Cohort (n=57)
Blinded outcome assessment
No
Does the presence of pulmonary hypertension impact survival outcomes in children experiencing in-hospital cardiac arrest?
Odds Ratio: 1.3 (95% CI 0.25–6.69)
Absolute Event Rate: 70% vs 65%
p-value: p=0.77
In children with in-hospital cardiac arrest, preceding pulmonary hypertension physiology is common but was not associated with worse survival outcomes in a cohort frequently treated with inhaled nitric oxide.
Pulmonary hypertension should not yet alter resuscitation intensity in pediatric in-hospital cardiac arrest; leaves open the impact of targeted therapies like nitric oxide.
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Morgan et al. (2019) conducted a cohort in Pediatric in-hospital cardiac arrest (n=57). Pulmonary hypertension vs. No pulmonary hypertension was evaluated on Event survival (adjusted OR 1.30, 95% CI 0.25-6.69, p=0.77). Preceding pulmonary hypertension was not associated with event survival (70% vs 65%; adjusted OR 1.30; 95% CI 0.25-6.69; p=0.77) in children with in-hospital cardiac arrest.
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