Key result
Cardioplegic arrest altered significantly more ventricular proteins in CAD patients (24 LV, 120 RV) compared to AVS patients (3 LV, 2 RV) despite a shorter ischemic period.
Why the study?
It was unknown whether cardiac disease remodeling affects acute proteomic changes during surgical intervention.
Does cardioplegic arrest and reperfusion trigger different proteomic and phosphoproteomic changes in the left and right ventricles of patients with CAD compared to AVS?
Comparison
Biopsies before ischemic cardioplegic arrest vs 20 min after reperfusion
Design
Proteomic and phosphoproteomic observational study
Follow-up
20 min after reperfusion
Authors
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May indicate heightened ventricular proteomic vulnerability to cardioplegia in CAD; hypothesis-generating and leaves open disease-specific protection trials.
Observational (n=12)
Yes
Does cardioplegic arrest and reperfusion trigger different proteomic and phosphoproteomic changes in the left and right ventricles of patients with CAD compared to AVS?
Ischemic arrest and reperfusion during cardiac surgery trigger markedly more proteomic and phosphoproteomic changes in the ventricles of CAD patients compared to AVS patients, highlighting disease-specific molecular responses to surgical stress.
Abdul‐Ghani et al. (2022) conducted an observational in Coronary artery disease or aortic valve stenosis (n=12). Ischemic cardioplegic arrest and reperfusion vs. Pre-ischemic baseline was evaluated on Differential expression of cardiac proteins and phosphoproteins. Cardioplegic arrest altered significantly more ventricular proteins in CAD patients (24 LV, 120 RV) compared to AVS patients (3 LV, 2 RV) despite a shorter ischemic period.
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