October 1, 2007Critical Care Medicine
Coronary artery disease progression is associated with increased resistance of hearts and myocytes to cardiac insults*
Why the study?
Does a high-fat diet inducing coronary artery disease alter the vulnerability of hearts and myocytes to cardiac insults in apolipoprotein E knockout mice?
Population
Male apolipoprotein E knockout mice, aged 8 wks
Comparison
High-fat diet for 24 wks vs Normal diet for 24 wks
Design
Preclinical
Follow-up
24 weeks
Authors
Discussion
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Member takes
Implication
May precondition diseased hearts against reperfusion injury in this model; leaves open translation to human CAD.
Structured PICO
Does a high-fat diet inducing coronary artery disease alter the vulnerability of hearts and myocytes to cardiac insults in apolipoprotein E knockout mice?
P
Population
Male apolipoprotein E knockout mice, aged 8 wks
I
Intervention
High-fat diet for 24 wks
C
Comparator
Normal diet for 24 wks
O
Outcome
Resistance to reperfusion injury (assessed by cardiac function, release of cardiac enzymes, and metabolic preservation)surrogate
Chronic partial ischemia from coronary artery disease progression may precondition hearts against subsequent acute cardiac insults.
Cite This Study
Chase et al. (2007) studied this question.