ApoE-/- mice on a high-fat diet serve as a valid model for chronic myocardial ischemia demonstrating significant T-wave depression correlating with lipid levels and atherosclerosis.
The ApoE-/- mouse fed a high-fat diet for 3 months serves as a viable and comprehensive small animal model for studying chronic myocardial ischemia driven by atherosclerosis.
Effect estimate: null (95% CI null)
p-value: p=<0.0001
Chronic myocardial ischemia (CMI) is a key pathological condition in coronary artery disease (CAD), yet small animal models for CMI are limited. This study developed and characterized a CMI mouse model using ApoE-/- mice fed a high-fat diet for 3 months. Cardiac function was assessed through electrocardiography (ECG), myocardial action potential, and perfusion echocardiography. The model group exhibited elevated cholesterol, aortic lipid plaques, and T-wave flattening, correlated with atherosclerosis severity. Impaired myocardial perfusion, reduced ATP content, and accelerated inner cardiomyocyte repolarization were also observed. PET/CT scans revealed filling defects, while myocardial contractile function showed reactive suppression under CMI conditions. This model replicates CMI's pathological features, providing a valuable tool for studying CAD progression and treatment.
Wang et al. (Thu,) conducted a other in Chronic myocardial ischemia (n=30). High-fat diet vs. C57BL/6 J mice on a standard diet was evaluated on T-wave depression measurements in ECG (null, 95% CI null, p=<0.0001). ApoE-/- mice on a high-fat diet serve as a valid model for chronic myocardial ischemia demonstrating significant T-wave depression correlating with lipid levels and atherosclerosis.