Key result
The combination of orthostatic systolic blood pressure decline and elevated resting heart rate increased the risk of first incident low-energy fractures by 30% between the highest and lowest quartiles.
Why the study?
Do orthostatic blood pressure decline and elevated resting heart rate predict incident low-energy fractures in a middle-aged population?
Cohort (n=33,139)
No
Do orthostatic blood pressure decline and elevated resting heart rate predict incident low-energy fractures in a middle-aged population?
Hazard Ratio: 1.3 (95% CI 1.08–1.57)
p-value: p=<0.001
Orthostatic hypotension and elevated resting heart rate independently predict long-term risk of low-energy fractures, suggesting they may serve as clinical markers for fall and fracture risk.
No takes yet. Share an insight, caveat, or question.
May flag higher fracture risk via routine vitals; hypothesis-generating and requires prospective validation before clinical use.
Hamrefors et al. (2016) conducted a cohort in Low-energy fractures (n=33,139). Orthostatic blood pressure decrease and elevated resting heart rate vs. Lowest quartiles of resting heart rate and orthostatic systolic blood pressure decrease was evaluated on First incident low-energy fracture (comparing extremes of combined resting heart rate and orthostatic systolic blood pressure decrease) (HR 1.30, 95% CI 1.08-1.57, p=<0.001). The combination of orthostatic systolic blood pressure decline and elevated resting heart rate increased the risk of first incident low-energy fractures by 30% between the highest and lowest quartiles.
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