Key result
Preinjury DOACs linked to less immediate ICH and fewer surgeries versus VKAs in elderly TBI patients.
Why the study?
With increasing cases of TBI in elderly patients taking anticoagulants, there is a need to better understand the safety of new anticoagulants and how to manage anticoagulated TBI patients.
Does preinjury use of DOACs improve outcomes following TBI in elderly patients compared to VKAs?
Meta-Analysis
Does preinjury use of DOACs improve outcomes following TBI in elderly patients compared to VKAs?
p-value: p=0.02
In elderly patients suffering traumatic brain injury, preinjury use of DOACs is associated with a lower risk of immediate intracranial hemorrhage, fewer surgical interventions, and shorter hospital stays compared to VKAs.
May support preferring DOACs over VKAs in fall-prone elderly; leaves open need for prospective confirmation.
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Karamian et al. (2024) conducted a meta-analysis in Traumatic brain injury. DOACs vs. VKAs was evaluated on Immediate ICH, surgical interventions, and hospital stay (p=0.02). Preinjury use of DOACs was associated with a lower risk of immediate ICH and surgical interventions, and a shorter hospital stay compared to VKAs in elderly patients with TBI (P=0.02).
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