Adipose tissue hypoxia is a hallmark of obesity, and modulating hypoxia signaling may serve as a therapeutic avenue to promote adipose health and improve obesity-related outcomes.
Modulating hypoxia signaling in adipose tissue represents a potential therapeutic avenue to improve outcomes related to obesity and its cardiovascular complications.
Obesity per se is rapidly emerging all over the planet and further accounts for many other life-threatening conditions, such as diabetes, cardiovascular diseases, and cancers. Decreased oxygen supply or increased relative oxygen consumption in the adipose tissue results in adipose tissue hypoxia, which is a hallmark of obesity. This review aims to provide an up-to-date overview of the hypoxia signaling in the adipose tissue. First, we summarize literature evidence to demonstrate that hypoxia is regularly observed during adipose tissue remodeling in humans and rodent models with obesity. Next, we discuss how hypoxia-inducible factors (HIFs) are regulated and how adipose tissues behave in response to hypoxia. Then, the differential roles of adipose HIF-1α and HIF-2α in adipose tissue biology and obesity pathology are highlighted. Finally, the review emphasizes the importance of modulating adipose hypoxia as a therapeutic avenue to assist adipose tissues in functionally adapting to hypoxic conditions, ultimately promoting adipose health and improving outcomes due to obesity.
Huynh et al. (Thu,) conducted a review in Obesity and adipose tissue hypoxia. Adipose tissue hypoxia was evaluated. Adipose tissue hypoxia is a hallmark of obesity, and modulating hypoxia signaling may serve as a therapeutic avenue to promote adipose health and improve obesity-related outcomes.