Key result
Cellular hypoxia in expanding adipose tissue is proposed as a key underlying cause of adipocyte dysfunction, leading to altered adipokine secretion, inflammation, and insulin resistance in obesity.
Population
Animal models and cell-culture systems representing obesity
Comparison
Cellular hypoxia (e.g., 1% O2 tension) vs Normoxia
Design
Review
Authors
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Preclinical data position adipose hypoxia as a research target in obesity; should not yet change practice.
Cellular hypoxia in expanding adipose tissue may be a fundamental mechanism driving the chronic low-grade inflammation and insulin resistance associated with obesity.
Wood et al. (2009) conducted a review in Obesity. Cellular hypoxia vs. Normoxia was evaluated. Cellular hypoxia in expanding adipose tissue is proposed as a key underlying cause of adipocyte dysfunction, leading to altered adipokine secretion, inflammation, and insulin resistance in obesity.
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