Key result
Adipose tissue hypoxia links fat expansion to adipose dysfunction and insulin resistance in obesity.
Why the study?
The mechanisms and sequence of events leading to inflammation and insulin resistance in obesity remain unknown, with adipose tissue hypoxia proposed as a key event in fat expansion and dysfunction.
This review summarizes the evidence on adipose tissue hypoxia as a potential mechanism linking obesity to inflammation and insulin resistance.
Adipose hypoxia remains a hypothesis in obesity-related insulin resistance; leaves open need for interventional human validation before clinical relevance.
Despite the well-established association of obesity with insulin resistance and inflammation, the underlying mechanisms and sequence of events leading to inflammation and insulin resistance remain unknown. Adipose tissue hypoxia has been proposed as one of the possible key events during the process of fat expansion that leads to adipose tissue dysfunction. The focus of this paper is reviewing the evidence on adipose tissue hypoxia in obesity and its relation to insulin resistance.
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Neda Rasouli (2016) conducted a review in Obesity and insulin resistance. Adipose tissue hypoxia was evaluated. This review examines the evidence proposing adipose tissue hypoxia as a key event during fat expansion that leads to adipose tissue dysfunction and insulin resistance in obesity.
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