Key result
Eccentric exercise, which utilizes the high force and low energy cost properties of titin, is an effective intervention for sports injury rehabilitation and preventing muscle and bone loss.
This review highlights the role of the giant titin protein in eccentric muscle contractions, explaining their high force and low energy cost through mechanisms like the winding filament hypothesis.
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May support eccentric protocols in rehab; leaves open RCTs to confirm titin-mediated outcomes.
Hessel et al. (2017) conducted a review in Muscle atrophy, sports injuries, and space travel-induced osteopenia/sarcopenia. Eccentric exercise vs. Conventional concentric interventions or standard therapy was evaluated. Eccentric exercise, which utilizes the high force and low energy cost properties of titin, is an effective intervention for sports injury rehabilitation and preventing muscle and bone loss.
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