The large amount of work which has been carried out dealing with the various aspects of the physiology and pathology of cholesterol, leaves many points to be cleared up before an accurate understanding of this complex question is possible.It has long been known that cholesterol occurs in the blood and t'issues in two principal conditions; namely, free, and combined with the higher fatty acids as cholesterol oleate, palmit.ate,and stearate.'Little or nothing is known concerning the importance of the relat,ive proport,ions of t.hcse two forms.Until the elaboration by Winclaus in 1910 of a quantitative method which made possible the determinat'ion of the two fractions separately, it was impossible to obtain any accurate information on the point.Since Ohat time ma,ny interesting investigations have been carried out, principally upon the cholesterol of blood in diverse physiological and pathological conditions, by Gardner and co-morl~ers,3 Henes,4 Havers,5 and others.There is as yet, however, no clear conception of the origin of the esters of cholest,erol in the body, nor of their possible reconversion into free cholesterol.As a result of the workof Gardner and others, it is now pretty definitely cstablishcd that 1 K. Hiirthle:
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J. Howard Mueller (1915) studied this question.